"Animadversions of a Synthetic Chemist"

From James Tour:

Life requires carbohydrates, nucleic acids, lipids, and proteins. What is the chemistry behind their origin? Biologists seem to think that there are well-understood prebiotic molecular mechanisms for their synthesis. They have been grossly misinformed. And no wonder: few biologists have ever synthesized a complex molecule ab initio. If they need a molecule, they purchase molecular synthesis kits, which are, of course, designed by synthetic chemists, and which feature simplistic protocols.

Polysaccharides? Their origin?

The synthetic chemists do not have a pathway.

The biologists do not have a clue.

[...]

Those who think scientists understand the issues of prebiotic chemistry are wholly misinformed. Nobody understands them. Maybe one day we will. But that day is far from today. It would be far more helpful (and hopeful) to expose students to the massive gaps in our understanding. They may find a firmer—and possibly a radically different—scientific theory.

The basis upon which we as scientists are relying is so shaky that we must openly state the situation for what it is: it is a mystery.