Jonathan McLatchie recently did a webinar with Intelligent design theorist and young-earth creationist Paul Nelson:
Between about about the 1 hr 46 min mark until about 2 hr 18 min, Nelson had an impromptu debate with Darwinian biologist and militant atheist Zachary Moore.
i) I believe Moore's impediment is the assumption that direct causation is impossible. For X to cause Y, there must be an intervening physical medium.
That, however, exhumes the ancient conundrum of infinite divisibility. Take particle physics. You can keep down down lower scales of matter and energy, but if you insist that cause-effect transactions require an intervening medium, then there's no ultimate explanatory terminus, for there must always be some physical medium in-between the cause and effect to facilitate the transaction.
ii) Another one of Zach's impediments, which Nelson kept returning to, is Zach's failure to distinguish what constitutes a scientific explanation given an ongoing cyclical process from what constitutes a scientific explanation of how that cyclical process originated. The fact that we may commonly require identification of a natural "mechanism" given the existence of a cyclical process does not imply that such a demand is reasonable to account for the given itself.
iii) Zach also missed the point of Nelson's SETI illustration. The point is that we'd be justified in inferring that signals from outer space transmitting Pi are the product of an advanced alien civilization even if we didn't an inkling about the technology by which they were able to transmit a signal that distant. You don't require the identification of a mechanism before you're warranted in inferring design or intelligent agency.