Doing business with the Beast

so that no one can buy or sell unless he has the mark, that is, the name of the beast or the number of its name (Rev 13:17).

Commentators who focus on the 1C context of the book debate what this is alluding to. I'd simply note that America is presently entering an era in which Christian businesses are subject to economic boycotts, or the functional equivalent (e.g. fines). 

Fines and economic boycotts can be very effective weapons to produce social conformity. After all, everyone must make a living to survive. 

How far this trend will develop in American society remains to be seen. There may be a rollback. Or it may become much worse. Depends on the level of popular resistance.